Mathematical Model to Calculate the Total Number of Radiation Decays of Radiolabelled-Pembrolizumab in Mice

Immunotherapy with checkpoint inhibitors Pembrolizumab shows potential to be used as a first-line in cancer treatment. A biodistribution study could maximize efficacy and minimize the risk of Therefore, it is necessary describe 89Zr-Pembrolizumab. This aims create mathematical model explain how 89Zr-pembrolizumab distributed body. Biodistribution data from Biokinetic 89Zr-Pembrolizumab NSG mice engrafted human lymphocyte peripheral (Hu-PBL-SCID) obtained literature were used. The organ compartment was divided into three sub-compartments: vascular, interstitial, endosomal space. estimated parameters plasma clearance (CL), endocytosis modulation factors (F2), exocytosis (F3) space, transcapillary flow (MK). According visualization fitted graphs percentage variation (CV) (50%), unknown successfully goodness fit method. value CL 2.65x10-5 l/h (CV=7.56%), parameter F2 for kidney, liver, spleen, muscle tissue range 0.12 - 0.35 (CV=4.14% 5.60%), while F3 3.60x10-3 0.036 (CV=2.21% 21.44%), factor (MK) within 8.26 46.91 (CV=0.98% 1.60%). mice.